Researchers have, for the first time, developed a method to 3D-print microscopic structures directly inside living human cells by injecting a biocompatible photoresin and using two-photon polymerization with a laser to solidify it into detailed shapes like barcodes, geometric forms, and even a tiny 10-micrometer elephant; many of the cells not only survived this process but continued to live and divide, passing the embedded structure to daughter cells.
This early proof-of-concept breakthrough could pave the way for entirely new intracellular bioengineering tools and applications, such as tracking cells with internal barcodes, probing cellular mechanics, creating microscopic machines or sensors inside cells, and eventually enabling advanced capabilities like targeted drug delivery or engineered biological functions beyond what is possible with current techniques.
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